Spain, making their first appearance in the round of 16 on Monday, opted to emphasise physicality in the contest against the premier side in international women's soccer, who are pursuing a fourth World Cup title, reports Efe news.
And while La Roja's rugged approach kept the match competitive, it also proved to be their undoing, as both US goals resulted from penalties.
Referee Katalin Kulcsar pointed to the spot in the seventh minute after Spain's Mapi Leon fouled Tobin Heath. Megan Rapinoe converted to give the defending champions an early lead in front of an overwhelmingly pro-US crowd at Stade Auguste-Delaune in Reims.
But the Spanish women were back on level terms just two minutes later thanks to a poor clearing attempt by US goalkeeper Alyssa Naeher.
The keeper saw her pass to Becky Sauerbrunn cut off by Lucia Garcia, leaving the ball for Jenni Hermoso, who tucked it into the top right corner for her third goal of the competition.
The equalizer buoyed Spain, who held firm despite losing midfielder Vicky Losada to injury in the 31st minute and managed to keep themselves in the match until Virginia Torrecilla fouled Rose Lavelle in the 70th minute.
Kulcsar awarded the penalty, only to then consult VAR, and the match clock was at 75 by the time Rapinoe took the kick to make it 2-1.
The outcome sets up a tantalizing quarterfinal clash between the US and host nation France, whose men's team hoisted the 2018 World Cup, set for next Sunday at Parc des Princes in Paris.
( With inputs from IANS )