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A team of researchers have developed a statistical framework to assess the performance of a diagnostic test with multiple observers.The study has been published in the 'Statistics in Medicine Journal'.The proposed method included an exploratory analysis, a statistical test of whether the observers' agreement percentage will plateau to a non-zero value, and a statistical model to estimate the agreement percentage and the number of observers for reaching the plateau.This method was applied in a non-small cell lung cancer example and a triple-negative breast cancer example using reads of the immunohistochemical tests with SP142 and SP263 assays for expression of Programmed death-ligand 1 (PD-L1) to determine the number of observers needed for evaluation of the subjective tests.The proposed method can indicate whether adding more observers to a test causes the proportion of agreement to plateau. Cases, where the curve does not plateau, could indicate an unreliable test. In cases where the curve does flatten, the method indicated at least how many observers are needed to reach a stable and reliable estimation of their agreement.A better understanding of how many observers are needed for optimal accuracy on a diagnostic test will help improve correct diagnosis, the right level of care and disease treatment. The authors, Gang Han and Bohong Guo believe that this method could be utilized by test creators and regulatory agencies to evaluate newly proposed subjective laboratory tests at different numbers of pathologists, which can ensure that the test will perform reliably in the real-world settings.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

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Technology :Study develops new method to improve accuracy of disease diagnosis

A team of researchers have developed a statistical framework to assess the performance of a diagnostic test with multiple observers. ...