Center for surgery and public health and division of cardiac surgery, Medical school in Brooklyn, New York

New York, Feb 29 People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries, suggests new research.The findings, published in the journal Drug Metabolism and Disposition, suggests that doctors need not always make patients with drug-induced liver injury stop taking all their medications until the liver healed.Drug-induced liver injury when a person accidentally harms their liver by taking medications prescribed by a doctor (or occasionally over the counter drugs) affects about almost 1 million people globally."Doctors give patients drugs to treat diseases. No one wants their liver damaged, but it happens all the time," said Xiaobo Zhong from the University of Connecticut in the US.When a person takes a medication by mouth, it goes into their stomach and then to the intestines, where it is absorbed into the blood.This blood, in turn, passes first through the liver before reaching the rest of the body. The liver has enzymes that break down medicines.But different people naturally have more or less of these enzymes. Sometimes, what could be a safe and effective dose in one person is too much for someone else who has different enzyme levels.This is why some individuals are more vulnerable to liver damage, even when taking drugs just as a doctor prescribed.There is no standard guidance for doctors when a patient gets drug-induced liver damage.Often times they tell the person to stop taking all medications immediately and wait for their liver to recover. But that can take weeks or months."But if patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control," if they stop taking the medications, Zhong said.And that can be life threatening.The researchers tested whether mice whose livers had been damaged by acetaminophen (the active ingredient in Tylenol) had lower levels of drug metabolising enzymes, called cytochrome P450 enzymes.The researchers investigated whether mice with drug-induced liver damage can safely take medications for diabetes, hypertension and depression.It looks like they can, as long as the doses are much smaller than normal, said the study.Because the damaged liver does not break down the medications as efficiently, they are just as effective at these lower doses.The team still has to test whether these results hold in humans.( With inputs from IANS )

Center For Surgery And Public Health And Division Of Cardiac SurgeryFOLLOW

Center for surgery and public health and division of cardiac surgery, Latest News

Amid the coronavirus outbreak, actor Amit Sadh has cancelled his New York trip where he's supposed to attend an acting workshop for two months. ...

(IANS) US President Donald Trump has declared a state of emergency over the novel coronavirus (COVID-19) outbreak in order to make more funds available for fighting the fallout of the disease while reflecting symbolically the seriousness of the situa ...

Expectant parents, please take note. You must address relationship anxiety before the first baby is born as researchers have revealed that a new child can spark feelings of jealousy in a person who already fears being abandoned by his or her partner. ...

Digital services and consulting major Infosys and IBM have announced a global alliance to help enterprises accelerate their digital transformation journey using the IBM public cloud. ...

Digital services and consulting major Infosys and IBM have announced a global alliance to help enterprises accelerate their digital transformation journey using the IBM public cloud. ...

Digital services and consulting major Infosys and IBM have announced a global alliance to help enterprises accelerate their digital transformation journey using the IBM public cloud. ...

Hollywood actor Nicolas Cage was photographed carrying a stuffed beluga and holding hands with mystery "girlfriend". ...

People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries, suggests new research. ...