Centre for microbiology and environmental systems science, State agency

Researchers have found that bacteria in the gut of premature infants may play a key role in the risk for brain damage.The findings of the study were published in the journal 'Cell Host and Microbe'.The research team found that the overgrowth of the gastrointestinal tract with the bacterium Klebsiella is associated with an increased presence of certain immune cells and the development of neurological damage in premature babies.The early development of the gut, the brain and the immune system are closely interrelated.Researchers refer to this as the gut-immune-brain axis. Bacteria in the gut cooperate with the immune system, which in turn monitors gut microbes and develops appropriate responses to them.In addition, the gut is in contact with the brain via the vagus nerve as well as via the immune system."We investigated the role this axis plays in the brain development of extreme preterm infants. The microorganisms of the gut microbiome -- which is a vital collection of hundreds of species of bacteria, fungi, viruses and other microbes -- are in equilibrium in healthy people." said the first author of the study, David Seki."However, especially in premature babies, whose immune system and microbiome have not been able to develop fully, shifts are quite likely to occur. These shifts may result in negative effects on the brain," explained the microbiologist and immunologist."In fact, we have been able to identify certain patterns in the microbiome and immune response that are clearly linked to the progression and severity of brain injury," said David Berry, microbiologist and head of the research group at the Centre for Microbiology and Environmental Systems Science (CMESS) at the University of Vienna as well as Operational Director of the Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna."Crucially, such patterns often show up prior to changes in the brain. This suggests a critical time window during which brain damage of extremely premature infants may be prevented from worsening or even avoided," added Berry.Starting points for the development of appropriate therapies are provided by the biomarkers that the interdisciplinary team was able to identify. "Our data show that excessive growth of the bacterium Klebsiella and the associated elevated ??-T-cell levels can apparently exacerbate brain damage," explained Lukas Wisgrill, Neonatologist from the Division of Neonatology, Pediatric Intensive Care Medicine and Neuropediatrics at the Department of Pediatric and Adolescent Medicine at the Medical University of Vienna."We were able to track down these patterns because, for a very specific group of newborns, for the first time we explored in detail how the gut microbiome, the immune system and the brain develop and how they interact in this process," he added.The study monitored a total of 60 premature infants, born before 28 weeks gestation and weighing less than 1 kilogram, for several weeks or even months.Using state-of-the-art methods -- the team examined the microbiome using 16S rRNA gene sequencing, among other methods -- the researchers analysed blood and stool samples, brain wave recordings (e.g. aEEG) and MRI images of the infants' brains.The study, which is an inter-university cluster project under the joint leadership of Angelika Berger (Medical University of Vienna) and David Berry (University of Vienna), is the starting point for a research project that will investigate the microbiome and its significance for the neurological development of prematurely born children even more thoroughly.In addition, the researchers will continue to follow the children of the initial study."How the children's motoric and cognitive skills develop only becomes apparent over several years. We aim to understand how this very early development of the gut-immune-brain axis plays out in the long term," explained Angelika Berger.The most important cooperation partners for the project are already on board. "The children's parents have supported us in the study with great interest and openness," said David Seki."Ultimately, this is the only reason we were able to gain these important insights. We are very grateful for that," concluded Seki.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Pahalgam Terror Attack

Tahawwur Rana

IPL 2025

CM Devendra Fadnavis

Mumbai Local

Weather Update

Centre For Microbiology And Environmental Systems ScienceFOLLOW

Centre for microbiology and environmental systems science, Latest News

International :Russians have looted and destroyed Chernobyl lab, says Ukraine

London, March 23 Russian troops occupying the Chernobyl nuclear power plant have "looted and destroyed" a laboratory at ... ...

National :Can Turkmenistan's new president get TAPI project back on track?

New Delhi, March 21: On March 19 Turkmenistan sworn in its new president. The country's vice Prime Minister Serdar ... ...

International :Russian forces take control of Chernobyl power plant

Russian forces have taken control of the Chernobyl power plant in northern Ukraine on Thursday (local time), as per an official. ...

Technology :Gut bacteria influences brain development in premature infants

During a recent study, researchers reached the conclusion that bacteria in the gut of premature infants might play a significant role in the risk for brain damage in them. ...

Technology :Researchers find gut bacteria influence brain development

Researchers have found that bacteria in the gut of premature infants may play a key role in the risk for brain damage. ...