Hong zhu - Latest News Update, Information, Photos & Videos on Hong zhu at Lokmat Times

Over the past 20 years, numerous complex cancer therapies known as antibody-drug conjugates (ADCs) have undergone clinical testing and been approved for use on patients. To explain the potential risks associated with these medications, researchers recently thoroughly examined different scientific databases.In CANCER, a peer-reviewed publication of the American Cancer Society, Wiley has published their research findings.An ADC has a complex structure comprised of an antibody that targets a protein expressed on cancer cells, a toxic compound to kill the targeted cells (also called a payload or warhead), and a linker to join the two. The clinical efficacy and toxicity of ADCs are affected by each component.In 2000, gemtuzumab ozogamicin was the first ADC approved by the US Food and Drug Administration, and more than a dozen ADCs have been approved worldwide to date. To investigate the side effects associated with different ADCs, a team led by Prof. Hong Zhu of Xiangya Hospital, Central South University, in China, conducted a systematic review and meta-analysis of published clinical trials of ADCs that reported treatment-related toxicities.The researchers uncovered 169 relevant trials involving 22,492 patients. The incidence of treatment-related adverse events was 91.2% for all events and 46.1% for serious adverse events (grade 3 or higher). The most common adverse events overall were lymphopenia (too few white blood cells), nausea, neutropenia (too few neutrophils, a type of white blood cell), vision blurriness, and peripheral neuropathy (nerve pain in the hands and feet). The most common serious adverse events were neutropenia, hypoesthesia (insensitivity), thrombocytopenia (too few blood platelets), neutropenia with fever, and lymphopenia. Certain ADCs were linked with higher average incidences of adverse events."Different ADCs appear to vary in their treatment-related adverse events. Our results provide an important reference for clinicians and patients on how to address ADCs' toxicity in clinical practice," said Prof. Zhu.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Pahalgam Terror Attack

Tahawwur Rana

IPL 2025

CM Devendra Fadnavis

Mumbai Local

Weather Update

Hong ZhuFOLLOW

Hong zhu, Latest News

Health :Researchers reveal effects of antibody drug conjugates- cancer therapies

Over the past 20 years, numerous complex cancer therapies known as antibody-drug conjugates (ADCs) have undergone clinical testing and ... ...