Jacob George - Latest News Update, Information, Photos & Videos on Jacob George at Lokmat Times

"Lean fatty liver patients have a very distinct metabolism compared to non-lean ones, which can explain some of the differences we see in disease progression," said Jacob George, Professor at the Westmead Institute for Medical Research in Australia.Fatty liver disease - a condition characterised by a build-up of fat in the liver - affects a quarter of the world's population.Although it commonly develops in overweight and obese people, many individuals with a Body Mass Index (BMI) of less than 25kg/m2 develop the disease and tend to have worse outcomes compared to obese patients.During the study, researchers compared the metabolism, gut bacteria and genetic profiles of patients with lean and non-lean fatty liver disease to determine factors that contribute to disease development and progression.Compared to non-lean patients, lean patients had higher levels of bile acids, which play a role in the digestion of fats, and a protein called fibroblast growth factor 19 (FGF19).According to the study published in the Journal of Hepatology, Bile acids and FGF19 increase energy expenditure, which can explain why lean individuals with fatty liver disease stay lean.This suggests that lean patients with a fatty liver may have an 'obesity-resistant' profile and better adaptation to an excess intake of calories."We also identified changes in particular gut bacteria and novel genes that can influence the development of fatty liver disease in lean patients. For example, we identified that a variant in the gene TM6SF2, previously linked to fatty liver disease, is more common in lean patients," said co-lead researcher Mohammed Eslam.Without treatment, fatty liver disease can result in liver scarring, liver cirrhosis and, in severe cases, liver failure."The metabolic adaptive mechanisms in lean fatty liver disease tend to be lost in the late stages of the disease. This could explain why these patients have worse disease outcomes compared to their obese counterparts," Eslam said.( With inputs from IANS )

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Pahalgam Terror Attack

Tahawwur Rana

IPL 2025

CM Devendra Fadnavis

Mumbai Local

Weather Update

Jacob GeorgeFOLLOW

Jacob george, Latest News

Business :Eatopia Honey Jam Bags the Most Innovative Product Award at the World’s Largest Food Exhibition

New Delhi (India), March 13: The 28th edition of Gulfood held in Dubai from the 19th-23rd February 2024 witnessed ... ...

Business :Eatopia Honey Jam bags the Most Innovative Product Award at the World's Largest Food Exhibition

The 28th edition of Gulfood held in Dubai from the 19th-23rd February 2024 witnessed over 5000+ F&B exhibitors from 125 countries under one roof. At the exhibition, Eatopia Honey Jam won the "Most Innovative Product" under the Best Sauces, Condiments ...

Business :Eatopia announces its newest product launch, Superfood Millet Puffs, at Gulfood Exhibition, Dubai

The government of India announced 2023 as the International Year of Millets. In light of this event, the government has lined up millet-centric promotional activities across the country. ...

Health :This is why lean people get fatty liver disease

Researchers have discovered how fatty liver disease develops in lean people, aiding the development of potential treatments for these patients. ...