`journal of neurochemistry, Peer-reviewed journal

New York, March 5 A smoking cessation drug cytisine may help treat Parkinson's disease or stop its progression in women, say researchers, including an Indian-origin.The study, published in the Journal of Neurochemistry, showed that, in an animal-based model, the drug reduces the loss of dopamine neurons in females, which indicates it as a potential evidence for the use of the drug to treat Parkinson's disease."What cytisine does is it binds to target receptors but doesn't activate them as efficiently as nicotine," said researcher Rahul Srinivasan from the Texas A&M University in the US."It keeps the receptors 'occupied' and 'chaperones' them to the surface of the neuron. Since cytisine is a natural compound, is available quite freely and is pretty cheap, I decided to test this concept of chaperoning in an animal model of the disease to see if it works," Srinivasan added.For the study, the team artificially induced Parkinson's disease in animal models.During that time, they either gave them saline (salt water) or cytisine. Then, the researchers performed a series of behavioural experiments in order to see if there was any sort of protective effect on the animal models that were given cytisine.Their findings showed that there was a protective effect both in terms of reducing the Parkinsonian behaviours and also in terms of reducing the number of dopamine neurons lost. However, the protective effect of cytisine occurred only in female animal models, and not in the males.They discovered that the combination of cytisine and estrogen produces a stronger protective effect than cytisine and no estrogen.This explains why the effect only occurred in female animal models, since males do not have appreciable amounts of estrogen, the researcher said.Although their findings currently only apply to females, the researcher hopes to find solutions for males and postmenopausal females, too.( With inputs from IANS )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Pahalgam Terror Attack

Tahawwur Rana

IPL 2025

CM Devendra Fadnavis

Mumbai Local

Weather Update

`journal Of NeurochemistryFOLLOW

`journal of neurochemistry, Latest News

Lifestyle :Study identifies active compound in mushroom which can boost nerve growth

According to a study an active compound from an edible mushroom can boost nerve growth and enhance memory. The ... ...

Health :Smoking cessation drug may treat Parkinson's in women

New York, March 5 A smoking cessation drug cytisine may help treat Parkinson's disease or stop its progression in ... ...