Noelle selin, Chemist

Whenever an organic matter is burned such as in a wildfire, a power plant, a car's exhaust, or in daily cooking, the combustion releases polycyclic aromatic hydrocarbons (PAHs) -- a class of pollutants that are known to cause lung cancer.According to the research, 89 per cent of that cancer risk comes from other PAH compounds, many of which are not directly regulated.The findings of the study were published in the journal 'GeoHealth'.There are more than 100 known types of PAH compounds emitted daily into the atmosphere.Regulators, however, have historically relied on measurements of a single compound, benzo(a)pyrene, to gauge a community's risk of developing cancer from PAH exposure. Now MIT scientists have found that benzo(a)pyrene may be a poor indicator of this type of cancer risk.In a modelling study, the team has reported that benzo(a)pyrene plays a small part -- about 11 per cent -- in the global risk of developing PAH-associated cancer.Instead, 89 per cent of that cancer risk comes from other PAH compounds, many of which are not directly regulated.Interestingly, about 17 per cent of PAH-associated cancer risk comes from "degradation products" -- chemicals that are formed when emitted PAHs react in the atmosphere. Many of these degradation products can in fact be more toxic than the emitted PAH from which they formed.The team hopes the results will encourage scientists and regulators to look beyond benzo(a)pyrene, to consider a broader class of PAHs when assessing a community's cancer risk."Most of the regulatory science and standards for PAHs are based on benzo(a)pyrene levels. But that is a big blind spot that could lead you down a very wrong path in terms of assessing whether cancer risk is improving or not and whether it's relatively worse in one place than another," said study author Noelle Selin, a professor at MIT's Institute for Data, Systems and Society, and the Department of Earth, Atmospheric and Planetary Sciences.Selin's MIT co-authors include Jesse Kroll, Amy Hrdina, Ishwar Kohale, Forest White, and Bevin Engelward, and Jamie Kelly (who is now at University College London). Peter Ivatt and Mathew Evans at the University of York are also co-authors.Chemical pixelsBenzo(a)pyrene has historically been the poster chemical for PAH exposure. The compound's indicator status is largely based on early toxicology studies.But recent research suggests the chemical may not be the PAH representative that regulators have long relied upon."There has been a bit of evidence suggesting benzo(a)pyrene may not be very important, but this was from just a few field studies," said Kelly, a former postdoc in Selin's group and the study's lead author.Kelly and his colleagues instead took a systematic approach to evaluate benzo(a)pyrene's suitability as a PAH indicator.The team began by using GEOS-Chem, a global, three-dimensional chemical transport model that breaks the world into individual grid boxes and simulates within each box the reactions and concentrations of chemicals in the atmosphere.They extended this model to include chemical descriptions of how various PAH compounds, including benzo(a)pyrene, would react in the atmosphere.The team then plugged in recent data from emissions inventories and meteorological observations and ran the model forward to simulate the concentrations of various PAH chemicals around the world over time.Risky reactionsIn their simulations, the researchers started with 16 relatively well-studied PAH chemicals, including benzo(a)pyrene, and traced the concentrations of these chemicals, plus the concentration of their degradation products over two generations, or chemical transformations. In total, the team evaluated 48 PAH species.They then compared these concentrations with actual concentrations of the same chemicals, recorded by monitoring stations around the world.This comparison was close enough to show that the model's concentration predictions were realistic.Then within each model's grid box, the researchers related the concentration of each PAH chemical to its associated cancer risk; to do this, they had to develop a new method based on previous studies in the literature to avoid double-counting risk from the different chemicals.Finally, they overlaid population density maps to predict the number of cancer cases globally, based on the concentration and toxicity of a specific PAH chemical in each location.Dividing the cancer cases by population produced the cancer risk associated with that chemical.In this way, the team calculated the cancer risk for each of the 48 compounds, then determined each chemical's individual contribution to the total risk.This analysis revealed that benzo(a)pyrene had a surprisingly small contribution, of about 11 per cent, to the overall risk of developing cancer from PAH exposure globally.Eighty-nine per cent of cancer risk came from other chemicals. And 17 per cent of this risk arose from degradation products."We see places where you can find concentrations of benzo(a)pyrene are lower, but the risk is higher because of these degradation products," Selin said."These products can be orders of magnitude more toxic, so the fact that they're at tiny concentrations doesn't mean you can write them off," Selin added.When the researchers compared calculated PAH-associated cancer risks around the world, they found significant differences depending on whether that risk calculation was based solely on concentrations of benzo(a)pyrene or on a region's broader mix of PAH compounds."If you use the old method, you would find the lifetime cancer risk is 3.5 times higher in Hong Kong versus southern India, but taking into account the differences in PAH mixtures, you get a difference of 12 times," Kelly said."So, there's a big difference in the relative cancer risk between the two places. And we think it's important to expand the group of compounds that regulators are thinking about, beyond just a single chemical," Kelly added.This research was conducted in MIT's Superfund Research Center and is supported in part by the National Institute of Environmental Health Sciences Superfund Basic Research Program, and the National Institutes of Health.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

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