Oxford univers, Company

Several non-genetic factors, including greater red meat intake, lower educational attainment, and heavier alcohol use are linked with an increased risk of colorectal cancer in people under 50, suggested a new study.The findings of the study were published by Oxford University Press in a new paper in JNCI Cancer Spectrum.In the United States, incidence rates of early-onset colorectal cancer have nearly doubled between 1992 and 2013 (from 8.6 to 13.1 per 100,000), with most of this increase due to early-onset cancers of the rectum. Approximately 1 in 10 diagnoses of colorectal cancer in this country occurs in people under 50.Researchers have observed the rise particularly among people born since the 1960s in studies from the United States, Canada, Australia, and Japan. During the same period, there have been major changes in diets among younger generations across the developing world.Such changes include decreases in consumption of fruits, non-potato vegetables, and calcium-rich dairy sources. This is coupled with an increase in processed foods (e.g., meats, pizza, macaroni and cheese, etc.) and soft drinks. Average nutrient intakes of fiber, folate, and calcium among the U.S. population are also lower than recommended.The increase in early-onset colorectal cancer is concerning to researchers because these cancers often have worse outcomes than those diagnosed in older people. It has led to recommendations that colorectal cancer screening begins at younger ages.Previous research has outlined potential risk factors for early-onset colorectal cancer including greater consumption of processed meat, reduced consumption of vegetables and citrus fruit, greater body mass index, sedentary lifestyles, greater alcohol use, smoking, reduced aspirin use, and diabetes. However, researchers have yet to perform a comprehensive, large-scale evaluation that compares the magnitude of these risks with those for late-onset colorectal cancer and assesses whether the risks for early-onset colorectal cancer correlate with specific types of colorectal cancer.Using data pooled from 13 population-based studies, researchers here studied 3,767 colorectal cancer cases and 4,049 controls in people under 50 and 23,437 colorectal cancer cases and 35,311 controls in people 50 or above years.Early-onset colorectal cancer was associated with not regularly using aspirins, greater red meat intake, lower educational attainment, heavier alcohol use, and (interestingly enough) also alcohol abstinence. Researchers also found that lower total fiber intake was linked more strongly to rectal than colon cancer.Several other colorectal cancer risk factors trended toward an association with early-onset colorectal cancer, including the history of diabetes and lower folate, dietary fiber, and calcium intake. However, neither BMI nor smoking were risk factors in the early-onset group, in contrast to the late-onset group.According to Richard Hayes, the senior investigator for this research: "this first large-scale study of non-genetic risk factors for early-onset colorectal cancer is providing the initial basis for targeted identification of those most at risk, which is imperative in mitigating the rising burden of this disease."( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Oxford UniversFOLLOW

Oxford univers, Latest News

Prabhuji Online, India's fastest growing technology enabled "Subscription Commerce Company", has raised an undisclosed amount of funds in pre-series A round from Singapore and India based marquee angel investors. ...

Godfrey Phillips India bags the coveted title of Best Companies to Work For 2021. Participating for the third year, Godfrey Phillips India received a ranking of 28th this year. ...

Lasa Supergenerics Limited (BSE: 540702, NSE: LASA), pioneer and amongst the leading players in the manufacturing of Veterinary and Human APIs in India through its catalyst chemistry expertise and fully backward integrated unit, has added another pro ...

Mumbai, June 7 ICICI Prudential Life Insurance has announced an annual bonus of Rs 867 crore for all ... ...

Mumbai, June 1 Covid's second wave, along with high fuel prices, dented the sequential growth of major automobile ... ...

Lasa Supergenerics Limited, a vertically integrated group spanning the entire animal and human healthcare value chain has announced its financial results for the fourth quarter and Financial Year ended March 31, 2021. ...

TVS Motor Company registered sales of 166,889 units in May 2021 as against sales of 58,906 units in the month of May 2020. Domestic sales in May 2021 is lower due to lockdowns in many states, but retails continue to be ahead of despatch. We have redu ...

Several non-genetic factors, including greater red meat intake, lower educational attainment, and heavier alcohol use are linked with an increased risk of colorectal cancer in people under 50, suggested a new study. ...