Sube banerjee, Researcher

A drug used to treat agitation in people with dementia is no more effective than a placebo, and might even increase mortality, according to a new study.The research, led by the University of Plymouth and published in the journal The Lancet, has shown that antidepressant mirtazapine offered no improvement in agitation for people with dementia - and was possibly more likely to be associated with mortality than no intervention at all.Agitation is a common symptom of dementia, characterised by inappropriate verbal, vocal, or motor activity, and often involves physical and verbal aggression. Non-drug patient-centered care is the first intervention that should be offered but, when this doesn't work, clinicians may move to a drug-based alternative.Antipsychotics have proven to increase death rates in those with dementia, along with other poor outcomes, and so mirtazapine has been routinely prescribed. This study was designed to add to the evidence base around its effectiveness.Funded by the National Institute for Health Research (NIHR), the study recruited 204 people with probable or possible Alzheimer's disease from 20 sites around the UK, allocating half to mirtazapine and half to placebo. The trial was double-blind; meaning that neither the researcher nor the study participants knew what they were taking.The results showed that there was no less agitation after 12 weeks in the mirtazapine group than in the control group. There were also more deaths in the mirtazapine group (seven) by week 16 than in the control group (only one), with analysis suggesting this was of marginal statistical significance.Lead researcher Professor Sube Banerjee, Executive Dean of the Faculty of Health and Professor in Dementia at the University of Plymouth, explained why the results were so surprising but important."Dementia affects 46 million people worldwide - a figure set to double over the next 20 years. Poor life quality is driven by problems like agitation and we need to find ways to help those affected," he said.This study shows that a common way of managing symptoms is not helpful - and could even be detrimental. It's really important that these results are taken into account and mirtazapine is no longer used to treat agitation in people with dementia."This study has added important information to the evidence base, and we look forward to investigating further treatments that may help to improve people's quality of life," Banerjee added.( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Pahalgam Terror Attack

Tahawwur Rana

IPL 2025

CM Devendra Fadnavis

Mumbai Local

Weather Update

Sube Banerjee, NewsFOLLOW

Sube banerjee, Latest News

Health :Commonly used antidepressant not effective in treating dementia: Lancet

London, Oct 24 A drug used to treat agitation in people with dementia is no more effective than ... ...

Health :Common antidepressant should no longer be used to treat people with dementia, says study

A drug used to treat agitation in people with dementia is no more effective than a placebo, and might even increase mortality, according to a new study. ...