University of cincinnati college of medicine, Public university in Cincinnati, Ohio

Researchers at the University of Cincinnati have tested a new combination therapy in mal models to see if they could find a way to make an already effective treatment even better.Since they're using a Food and Drug Administration-approved drug to do it, this could help humans sooner than later.These findings are published in the journal Cancer Letters.Christina Wicker, PhD, a postdoctoral fellow in the lab of Vinita Takiar, MD, PhD, led this research which she says will hopefully extend the lives of patients one day."Head and neck cancer, like any cancer, is truly life-altering," she says. "Head and neck cancer could impact your throat, tongue or nose, and patients often can't swallow, talk or eat; it truly takes away some of the most social, enjoyable parts of life."Researchers in this study combined radiation therapy with a drug (telaglenastat) that stops a key enzyme in a cell pathway that becomes altered in cancer cells, causing those cells to grow rapidly and resist treatment. Wicker says this drug has already been studied in multiple clinical trials to see if it could improve treatment of various cancers."Until now, no one has examined if this drug has the potential to improve radiation treatment in head and neck cancer. Most importantly, this drug compound has been well tolerated by patients and causes minimal side effects," she says.Using mal models, researchers found that the drug alone reduced the growth of head and neck cancer cells up to 90 per cent, and it also increased the efficacy of radiation in mals with head and neck tumours by 40 per cent"With these results, and especially with previous clinical trials showing that the drug is well tolerated by patients, there is the potential to move more rapidly into head and neck cancer clinical trials," Wicker says."In the future, we hope this drug will be used to make radiation treatments for head and neck cancer even more effective."Currently, the most common treatment for that cancer is radiation therapy, but cancer eventually returns in up to half of the patients, Wicker says, and often it doesn't respond as positively to treatment the second time around."When [traditional] drugs are less effective, cancer growth becomes difficult to control, which can lead to the cancer quickly spreading to other organs," she says."It is very important that scientists and clinicians develop new cancer treatments to improve treatment of this type of cancer, and hopefully our findings will provide one more option to help patients."( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

University Of Cincinnati College Of MedicineFOLLOW

University of cincinnati college of medicine, Latest News

While there are plenty of negatives associated with smart technology, there is also a positive side to it, according to a new University of Cincinnati research by social and behavioural expert Anthony Chemero. ...

According to a new University of Cincinnati research by social/behavioural expert Anthony Chemero, while there are plenty of negatives associated with smart technology, there is also a positive side to it. ...

University of Cincinnati researchers have found a newer, more effective treatment for the disease Pompe that could become the new standard of care for the rare condition. ...

University of Cincinnati researchers have found a newer, more effective treatment for the disease Pompe that could become the new standard of care for the rare condition. ...

The findings of a recent study by a University of Cincinnati toxicologist suggests that finding an 'eliciting dose' may help those who suffer mild or moderate allergic reactions to peanut. ...

According to a new study, tobacco smoke-exposed children utilise emergency and urgent care services more often than unexposed children, which contributes to a large toll on the nation's health care system. ...

New York, Jan 23 Researchers have tested a new combination therapy that showed reduced growth of head and ... ...

Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. ...