Us Secretary Of State - Latest News Update, Information, Photos & Videos on Us Secretary Of State at Lokmat Times

Los Angeles [US], July 9 : Cryo-EM, a powerful microscopy technique, was used by researchers to decode the molecular architecture of a transporter protein that controls the movement of a key neurotransmitter.The findings were published in the journal, 'Nature Structural & Molecular Biology.'Neurotransmitters are chemical signals that allow neurons or nerve cells to communicate with one another. Each neurotransmitter can activate specific groups of proteins known as receptors, which can either excite or inhibit neural communication. For neural circuitry to maintain normal structure and function, a healthy balance of excitation and inhibition is required. Seizures, anxiety, and schizophrenia can all result from excitatory or inhibitory input imbalances.GABA, an inhibitory neurotransmitter, balances out the excitatory inputs from glutamate, another neurotransmitter. GABA receptor proteins interact with GABA released from preceding neurons in the circuit to modulate GABA-driven signalling at neural synapses (junctions between neurons). For subsequent release events to occur, excess GABA released into neural synapses must be recycled into neurons and surrounding glial cells. The primary molecules involved in this step are GABA transporters (GATs), which use sodium and chloride ions to move excess GABA back into neurons. As a result, GATs are critical molecules that orchestrate GABA signalling and function. As a result, they are an important target for the treatment of conditions such as seizures.The current study, led by Aravind Penmatsa, Associate Professor in the Molecular Biophysics Unit (MBU), IISc, deciphers the molecular architecture of GAT using cryo-electron microscopy. The technique has the capacity to image and reconstruct the structure of biomolecules that are more than a million times smaller than the width of a human hair.The researchers purified GAT and used a novel approach to create an antibody site on this molecule. Antibodies help increase the mass of proteins and facilitate improved imaging through cryo-EM. The team observed that the GAT structure was facing the cytosol - the inside of the cell - and was bound to a GABA molecule, sodium and chloride ions. This binding is one of many key steps in the GABA transport cycle; deciphering it can provide vital insights into the mechanisms of GABA recognition and release into neurons.The availability of high-resolution GAT structures is crucial for developing specific blockers of GABA uptake to treat epilepsies. It would also aid in studying how drugs prescribed to block GABA uptake interact with GATs.Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

Us Secretary Of StateFOLLOW

Us secretary of state, Latest News

Washington [US], July 10 : According to studies, body mass index (BMI) is not a full indicator of metabolic ... ...

Sanaa, July 10 The Yemeni riyal has plummeted to a new low against the US dollar, raising ... ...

Washington [US], July 10 : Researchers discovered that the plastic mulch used to help Californian strawberries grow sheds ... ...

Washington [US], July 10 : The material a bird chooses for its nest is determined by the size of ... ...

Washington [US], July 10 : American actor, Jamie Foxx appears to be doing well after his mysterious medical complication ... ...

New Delhi [India], July 10 : Chandrayaan-3, scheduled to be launched from Sriharikota this week, will make "India the ... ...

Washington [US], July 9 : Canadian rapper Drake defended his pink manicure after friend and rapper Lil Yachty made ... ...

Los Angeles [US], July 9 : Cryo-EM, a powerful microscopy technique, was used by researchers to decode the molecular ... ...