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Researchers at the Utah State University recently used the silk from silkworm to grow skeletal muscle cells, improving on traditional methods of cell culture and hopefully leading to better treatments for muscle atrophy.When scientists are trying to understand the disease and test treatments, they generally grow model cells on a flat plastic surface (think petri dish). But growing cells on a two-dimensional surface has its limitations, primarily because muscle tissue is three-dimensional.Thus, USU researchers developed a three-dimensional cell culture surface by growing cells on silk fibers that are wrapped around an acrylic chassis. The team used both native and transgenic silkworm silk, the latter produced by silkworms modified with spider silk genes.Native silkworm silks have been used previously as three-dimensional cell culture models, but this is the first time that transgenic silkworm silk has been used for skeletal muscle modeling. Elizabeth Vargis, Matthew Clegg, and Jacob Barney of the Biological Engineering Department, and Justin Jones, Thomas Harris, and Xiaoli Zhang of the Biology Department published their findings in ACS Biomaterials Science and Engineering.Cells grown on silkworm silk proved to more closely mimic human skeletal muscle than those grown on the usual plastic surface. These cells showed increased mechcal flexibility and increased expression of genes required for muscle contraction. Silkworm silk also encouraged proper muscle fiber alignment, a necessary element for robust muscle modeling.Skeletal muscle is responsible for moving the skeleton, stabilizing joints, and protecting internal organs. The deterioration of these muscles can happen for myriad reasons, and it can happen swiftly. For example, after only two weeks of immobilization, a person can lose almost a quarter of their quadricep muscle strength. Understanding how muscles can atrophy so quickly must begin at a cellular level, with cells grown to better represent reality."The overarching goal of my research is to build better in vitro models," said Elizabeth Vargis, associate professor of biological engineering at USU. "Researchers grow cells on these 2D platforms, which aren't super realistic, but give us a lot of information. Based on those results, they usually transition into an mal model, then they move onto clinical trials, where a vast majority of them fail. I'm trying to add to that first step by developing more realistic in vitro models of normal and diseased tissue."( With inputs from ANI )Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

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Health :Researchers find silkworm silk may help better treatment of muscle atrophy

In a step to discover the method to improve on traditional methods of cell culture, the researchers at the Utah State University recently used the silk from silkworm to grow skeletal muscle cells. The results of the study may hopefully lead to better ...

Health :Researchers find silkworm silk may help better treatment of muscle atrophy

In a step to discover the method to improve on traditional methods of cell culture, the researchers at the Utah State University recently used the silk from silkworm to grow skeletal muscle cells. The results of the study may hopefully lead to better ...

Technology :Researchers use silkworm silk hoping for better treatment of muscle atrophy

Researchers at the Utah State University recently used the silk from silkworm to grow skeletal muscle cells, improving on traditional methods of cell culture and hopefully leading to better treatments for muscle atrophy. ...

Technology :Researchers use silkworm silk hoping for better treatment of muscle atrophy

Researchers at the Utah State University recently used the silk from silkworm to grow skeletal muscle cells, improving on traditional methods of cell culture and hopefully leading to better treatments for muscle atrophy. ...